Germline BARD1 Mutations Predispose to Mesothelioma by Impairing DNA Repair and Calcium Signaling

Ca: A Cancer Journal for Clinicians 2019

Asbestos: Risk Assessment, Epidemiology, and Health Effects

Translational Lung Cancer Research: Focused Issue

Did the Ban on Asbestos Reduce the Incidence of Mesothelioma?

Journal of Thoracic Oncology 2023

BAP1 is a novel regulator of HIF-1α

The Proceedings of the National Academy of Sciences in the USA 2023

BAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos

The Proceedings of the National Academy of Sciences in the USA 2021

BAP1 Regulates IP3R3-mediated Ca2+ Flux to Mitochondria Suppressing Cell Transformation

Nature: Cell Death and Disease 2017

Medical and Surgical Care of Mesothelioma Patients and their Relatives Carrying Germline BAP1 Mutations

Journal of Thoracic Oncology 2022

BAP1 Forms a Trimer with HMGB1 and HDAC1 that Modulates Gene ×Environment Interaction with Asbestos

Proceedings of the National Academy of Sciences in the USA 2021

Heterozygous Germline BLM Mutations Increase Susceptibility to Asbestos and Mesothelioma

Proceedings of the National Academy of Sciences in the USA 2020

Asbestos Induces Mesothelial Cell Transformation via HMGB1-driven Autophagy

Proceedings of the National Academy of Sciences in the USA 2020

Biological Mechanisms and Clinical Significance of BAP1 Mutations in Human Cancer

Cancer Discovery 2020

Tumour Predisposition and Cancer Syndromes as Models to Study Gene–Environment Interactions

Nature Reviews Cancer 2020

Mesothelioma: What We Know and What We Do Not Know in 2020

Translational Lung Cancer Research: Focused Issue

Coronavirus 2019 Infectious Disease Epidemic: Where We Are, What Can Be Done and Hope For

Journal of Thoracic Oncology 2021

Mesothelioma: Scientific Clues for Prevention, Diagnosis, and Therapy

Ca: A Cancer Journal for Clinicians 2019

BAP1 Regulates Different Mechanisms of Cell Death

Nature 2018

A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations

Journal of Clinical Oncology 2018

Consensus Report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction: Novel Opportunities for Precision Medicine in Carcinogenesis

Cell Death & Differentiation 2018

Inhibition of the Spindle Assembly Checkpoint Kinase Mps-1 as a Novel Therapeutic Strategy in Malignant Mesothelioma

Oncogene Short Communication 2017

Germline BAP1 Mutations Induce a Warburg Effect

Cell Death & Differentiation 2017

Diagnostic and Prognostic Biomarkers for Malignant Mesothelioma: AnUpdate

Translational Lung Cancer Research 2017

Our Team’s Work

A Review of our Projects, Publications, and Discoveries

Mesothelioma: Recent Highlights

Annals of Translational Medicine 2017

High-density Array-CGH with Targeted NGS Unmask Multiple Noncontiguous Minute Deletions on Chromosome 3p21 in Mesothelioma

JAMA Oncology 2017

FTY720 Inhibits Mesothelioma Growth in vitro and in a Syngeneic Mouse Model

Journal of Translational Medicine 2017

HMGB1 Targeting by Ethyl Pyruvate Suppresses Malignant Phenotype of Human Mesothelioma

Oncotarget 2017

Improving the Accuracy of Mesothelioma Diagnosis in China

Journal of Thoracic Oncology 2016

Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China

Journal of Thoracic Oncology 2016

Mesothelioma: Causes, Prevention, Screening and Early Detection

IASLC CME Webinar Powerpoint Presented by Drs. Michele Carbone & Harvey Pass

Eternot, the largest asbestos factory in Europe, is now covered by a beautiful playground.  The statue of a girl with a kite represents the hope that we can transform the negative into the positive and that life continues.

Statue by Italietta Corsani Carbone, Dr. Carbone’s mother.

learn about
Oak Park Pathology

This is Dr. Michele Carbone’s private website which provides detailed information about his work as a clinician and researcher.  Dr. Carbone is a board-certified Anatomic Pathologist and cancer researcher.  He is one of the world’s leading scientists in the area of mesothelioma, a cancer that is often associated with asbestos exposure.  His research into why most people who have been exposed to asbestos do not get mesothelioma has led him to investigation of interactions between genetics and the environment.  Over the years, Dr. Carbone’s research has focused on the role of human genetics in the development of malignant mesothelioma, as well as the mechanisms associated with the development of the disease.  Dr. Carbone received several consult requests per year from all over the world on challenging cases.  His diagnostic skills help him see the most unusual cases and develop new research hypotheses.


Dr. Carbone's research work posited and later proved that gene/environment interactions...
Learn More


Dr. Carbone has led multi-national, interdisciplinary teams to remote areas of the United States...
Learn More


Dr. Carbone’s team studies the biological mechanisms that are associated...
Learn More


Dr. Carbone has devoted much of his research career to the investigation of the causes...
Learn More

Years Experience
Academic Papers
Books & Journals
Book Chapters
Active Grants

Malignant Mesothelioma is a tumor associated with exposure to mineral fibers such as asbestos and erionite. 
In spite of stringent regulations introduced in the 1970s and 80s to limit asbestos exposure, the incidence of Malignant Mesothelioma reached 3,200 cases per year in the US in 2003 and it has remained stable since then. 
The incidence of Malignant Mesothelioma has also sharply increased worldwide over the past 50 years.

Who is Affected by Mesothelioma?

Read More

Causes of Mesothelioma

Read More

Mesothelioma of the Lungs & Pleura

Read More

Mesothelioma of the Peritoneum

Read More

The Role of Genetics in its Development

Read More

Treatment/Therapeutic Strategies

Read More


Register for access to Dr. Carbone’s blog articles.