Significance
There has been an unexplained increase of mesothelioma in younger patients who have not worked in the asbestos industry. We report that inherited germline mutations of BARD1 cause some mesotheliomas in young patients. They experience significantly prolonged survival up to 20+ y and they require tailored screening and therapeutic approaches.
Flavia Novelli, Yoshie Yoshikawa, Veronica Angela Maria Vitto, Lorenzo Modesti, Michael Minaai, Sandra Pastorino, Mitsuru Emi, Jin-Hee Kim, Franz Kricek, Fang Bai, José N. Onuchic, Angela Bononi, Joelle S. Suarez, Mika Tanji, Cristina Favaron, Alicia A. Zolondick, Ronghui Xu, Yasutaka Takanishi, Zhanwei Wang, Greg Sakamoto, Giovanni Gaudino, Joseph Grzymski, Federica Grosso, David S. Schrump, Harvey I. Pass, Lilit Atanesyan, Jan Smout, Suvi Savola, Kavita Y. Sarin, Hassan Abolhassani, Lennart Hammarström, Qiang Pan-Hammarström, Carlotta Giorgi, Paolo Pinton, Haining Yang, and Michele Carbone
July 11, 2024 | 121 (29) e240523112 | doi: https://doi.org/10.1073/pnas.2405231121