Significance
In this new manuscript, Dr. Carbone, and collaborators, discovered that mesotheliomas caused by inherited germline BAP1 mutations are a different and much less aggressive disease compared to sporadic mesotheliomas, and they discovered how to identify and diagnose these patients and how to best treat them. They found that in addition to mesothelioma, these patients develop multiple tumors and therefore it is critical that they are enrolled in screening programs for early cancer detection. They propose to re-name these tumors as “low-grade-BAP1-associated-mesotheliomas”, L-BAM- to distinguish them from the very aggressive sporadic asbestos-induced mesotheliomas which are resistant to therapy.
Authors:
Michele Carbone MD, PhD, Michael Minaai ,BS, Muaiad Kittaneh, MD, MBA, Thomas Krausz, MD, Markku M. Miettinen MD, Qiang Pan Hammarström MD, PhD, Lennart Hammarström MD, PhD, Hassan Abolhassani MD, MPH, PhD, Ian Pagano PhD, Ronghui Xu, MS, Flavia Novelli ,PhD, Giovanni Gaudino, PhD, Sandra Pastorino PhD, Kavita Y. Sarin MD, PhD, Robert T. Ripley MD, Harvey I. Pass MD, David S. Schrump MD, MBA, Haining Yang MD, PhD.
June 27, 2025 | https://www.sciencedirect.com/science/article/pii/S1556086425008081