We hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of MM, BAP1-associated cancers, or multiple malignancies; or age younger than 50 years old.
Authors: Sandra Pastorino, Yoshie Yoshikawa, Harvey I. Pass, Mitsuru Emi, Masaki Nasu, Ian Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Manaai, Tomoko Hashimoto-Tamaoki, Masaki Ohmuraya, Keisuke Goto, Chandra Goparaju, Kavita Y. Sarin, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Mary Hesdorffer, and Michele Carbone.
Cell Death and Differentiation, June 30, 2017 (doi: 10.1038/cdd.2017.95)
Aerobic glycolysis, also known as the ‘Warburg effect’, does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis.
published in Translational Lung Cancer Research, June 16, 2017
A review of the most promising biomarkers for early detection of malignant mesothelioma.
Nature International Weekly Journal of Science (2017) - doi:10.1038/nature22798
A mechanistic rationale for the ability of BAP1 to regulate gene-environment interaction in human carcinogenesis
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