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Dr. Michele Carbone's Scientific Publications

BAP1 regulates different mechanisms of cell death

BAP1 regulates different mechanisms of cell death

Cell Death & Disease, volume 9, Article number: 1151 (2018)

The ubiquitin carboxyl terminal BAP1 is a member of deubiquitinating enzymes superfamily, which are responsible for coordinating ubiquitin-signaling processes through the removal of ubiquitin from protein substrates. Studies of families with high incidence of mesothelioma led to the discovery that all affected family members carried heterozygous BAP1 mutations (BAP1+/−), a condition that was named “the BAP1 cancer syndrome”.

 

Since the initial discovery in 2011, over 100 families have been identified worldwide affected by the BAP1 cancer syndrome.

 

Authors: El Bachir Affar, Michele Carbone

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BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

Nature International Weekly Journal of Science (2017) - doi:10.1038/nature22798

A mechanistic rationale for the ability of BAP1 to regulate gene-environment interaction in human carcinogenesis

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Our Team's Work

Our Team's Work

A Review of our Projects, Publications, and Discoveries

A summary of the research and publications produced by our team over the last two years.

View our presentation - Carbone-Full-Presentation-06042017.pdf
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Mesothelioma: Recent Highlights

Mesothelioma: Recent Highlights

Annals of Translational Medicine 2017: Review Article

Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma. 
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View IASLC CME Webinar Powerpoint Presented by Drs. Michele Carbone & Harvey Pass

View IASLC CME Webinar Powerpoint Presented by Drs. Michele Carbone & Harvey Pass

Mesothelioma: Causes, Prevention, Screening and Early Detection

The International Association for the Study of Lung Cancer (IASLC) sponsored a live 60-minute CME webinar on November 15, 2016  featuring Dr. Michele Carbone, MD, PhD and Dr. Harvey I. Pass, MD .  The webinar describes clinical research efforts focusing on how mesothelioma prevention and intervention at earlier stages of the disease process may improve the management of mesothelioma.

 

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