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Dr. Michele Carbone's Scientific Publications

Oncotarget Advance Publication: HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

Oncotarget Advance Publication: HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma

We studied the effect of ethyl pyruvate (EP), the ethyl ester of pyruvic acid, on the malignant phenotype of MM cells in tissue culture and on tumor growth in vivo using an orthotopic MM xenograft model.
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Improving the accuracy of mesothelioma diagnosis in China

Improving the accuracy of mesothelioma diagnosis in China

Journal of Thoracic Oncology, December 24, 2016

There is concern that a proportion of MM diagnoses in China may be incorrect because most Chinese physicians do not have experience diagnosing this rare cancer. We recently reported an unusual high incidence of peritoneal MM among Eastern Chinese female patients. Here, we review the accuracy of MM diagnoses in China and provide suggestions to improve the accuracy of diagnosis.

 

 

 

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JAMA Oncology Research Letter

JAMA Oncology Research Letter

Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China

The reported incidence of malignant mesothelioma (MM) in China is 1.5 cases per million population, much lower than in other countries. In China, the prevalence of MM in different regions is unknown, and only 15% of MMs have been associated with asbestos exposure compared with more than 70% in most of the world
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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma

We found that gene mutations/deletions are frequent in mesothelioma and occur through a variety of DNA alterations. We identified genes implicated in malignant mesothelioma: SETD2, SMARCC1, PBRM1.
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View IASLC CME Webinar Powerpoint Presented by Drs. Michele Carbone & Harvey Pass

View IASLC CME Webinar Powerpoint Presented by Drs. Michele Carbone & Harvey Pass

Mesothelioma: Causes, Prevention, Screening and Early Detection

The International Association for the Study of Lung Cancer (IASLC) sponsored a live 60-minute CME webinar on November 15, 2016  featuring Dr. Michele Carbone, MD, PhD and Dr. Harvey I. Pass, MD .  The webinar describes clinical research efforts focusing on how mesothelioma prevention and intervention at earlier stages of the disease process may improve the management of mesothelioma.

 

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