Insights into fiber-induced carcinogenicity
Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada.
An emerging concern—epidemiological issues
Despite predictions of decline in mesothelioma following the ban of asbestos in most industrial countries, the incidence is still increasing globally, particularly in women.
Association of SV40 with human tumors
Meeting Report: Studies conducted by the various investigators were presented addressing the association of SV40 with human mesothelioma. Joseph Testa (Fox Chase Cancer Center, Philadelphia, PA, USA) reported the conclusions of a multi-laboratory study he had directed following the recommendation of the 1997 NIH conference (see Carbone et al. (1997b) for meeting review of 1997 NIH conference) and upon the request of the International Mesothelioma Interest Group (IMIG).
Authors: George Klein, Amy Powers and Carlo Croce
Cancer Research, November 2008: Volume 68, Issue 22
Suppression of the late gene expression, usually by integration of the viral DNA into the host genome, is a critical step in DNA tumor virus carcinogenesis. SV40 induces high rates of transformation in infected primary human mesothelial cells in tissue culture, leading to the formation of immortal cell lines (SV40-transformed human mesothelial cell lines, S-HML).
Opinion: Lessons from the Clinic
Malignant Mesothelioma is a rare and poorly understood cancer with limited therapeutic approaches.