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Dr. Michele Carbone's Scientific Publications

JAMA Oncology Research Letter

JAMA Oncology Research Letter

Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China

The reported incidence of malignant mesothelioma (MM) in China is 1.5 cases per million population, much lower than in other countries. In China, the prevalence of MM in different regions is unknown, and only 15% of MMs have been associated with asbestos exposure compared with more than 70% in most of the world
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Oncogene - Meeting Report:

Oncogene - Meeting Report:

Association of SV40 with human tumors

Meeting Report:   Studies conducted by the various investigators were presented addressing the association of SV40 with human mesothelioma. Joseph Testa (Fox Chase Cancer Center, Philadelphia, PA, USA) reported the conclusions of a multi-laboratory study he had directed following the recommendation of the 1997 NIH conference (see Carbone et al. (1997b) for meeting review of 1997 NIH conference) and upon the request of the International Mesothelioma Interest Group (IMIG).

 

Authors: George Klein, Amy Powers and Carlo Croce

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A Novel Mechanism of Late Gene Silencing Drives SV40 Transformation of Human Mesothelial Cells

A Novel Mechanism of Late Gene Silencing Drives SV40 Transformation of Human Mesothelial Cells

Cancer Research, November 2008: Volume 68, Issue 22

Suppression of the late gene expression, usually by integration of the viral DNA into the host genome, is a critical step in DNA tumor virus carcinogenesis. SV40 induces high rates of transformation in infected primary human mesothelial cells in tissue culture, leading to the formation of immortal cell lines (SV40-transformed human mesothelial cell lines, S-HML).

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SV40 and human tumours: myth, association or causality?

SV40 and human tumours: myth, association or causality?

Nature Reviews: Cancer (2002)

An increasing number of scientific reports have described evidence for a polyomavirus, simian virus 40, in a highly select group of human tumors. How did a simian virus infect humans and is the virus a passenger in tumours or is it important in their pathogenesis?

Authors:  Adi F. Gazdar, Janet S. Butel & Michele Carbone

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