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Dr. Michele Carbone's Scientific Publications

Oncogene Short Communication:

Oncogene Short Communication:

Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma

CFI-402257 is a promising novel therapeutic agent to improve the efficacy of the current chemotherapeutic regimens for MM patients.
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Germline BAP1 mutations induce a Warburg effect

Germline BAP1 mutations induce a Warburg effect

Cell Death and Differentiation, June 30, 2017 (doi: 10.1038/cdd.2017.95)

Aerobic glycolysis, also known as the ‘Warburg effect’, does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis.
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BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

Nature International Weekly Journal of Science (2017) - doi:10.1038/nature22798

A mechanistic rationale for the ability of BAP1 to regulate gene-environment interaction in human carcinogenesis

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Our Team's Work

Our Team's Work

A Review of our Projects, Publications, and Discoveries

A summary of the research and publications produced by our team over the last two years.

View our presentation - Carbone-Full-Presentation-06042017.pdf
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Mesothelioma: Recent Highlights

Mesothelioma: Recent Highlights

Annals of Translational Medicine 2017: Review Article

Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma. 
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