Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma
CFI-402257 is a promising novel therapeutic agent to improve the efficacy of the current chemotherapeutic regimens for MM patients.
Cell Death and Differentiation, June 30, 2017 (doi: 10.1038/cdd.2017.95)
Aerobic glycolysis, also known as the ‘Warburg effect’, does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis.
Nature International Weekly Journal of Science (2017) - doi:10.1038/nature22798
A mechanistic rationale for the ability of BAP1 to regulate gene-environment interaction in human carcinogenesis
A Review of our Projects, Publications, and Discoveries
Annals of Translational Medicine 2017: Review Article
Recent discoveries have elucidated some of the mechanisms responsible for the development of mesothelioma.