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Dr. Michele Carbone's Scientific Publications

Consensus report of the 8 and 9th Weinman Symposia on Gene xEnvironment Interaction: novel opportunities for precision medicine in carcinogenesis

Consensus report of the 8 and 9th Weinman Symposia on Gene xEnvironment Interaction: novel opportunities for precision medicine in carcinogenesis

For the past 10 years, the Virginia  & Barry Weinman Foundation, in conjunction with the University of Hawaii Cancer Center, has sponsored an annual meeting of top researchers from around the world. This publication in Cell Death & Differentiation (6 August 2018) is a consensus report about the role of genes and environment in carcinogenesis.

 

 

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Oncogene Short Communication:

Oncogene Short Communication:

Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma

CFI-402257 is a promising novel therapeutic agent to improve the efficacy of the current chemotherapeutic regimens for MM patients.
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Germline BAP1 mutations induce a Warburg effect

Germline BAP1 mutations induce a Warburg effect

Cell Death and Differentiation, June 30, 2017 (doi: 10.1038/cdd.2017.95)

Aerobic glycolysis, also known as the ‘Warburg effect’, does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis.
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BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

Nature International Weekly Journal of Science (2017) - doi:10.1038/nature22798

A mechanistic rationale for the ability of BAP1 to regulate gene-environment interaction in human carcinogenesis

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Our Team's Work

Our Team's Work

A Review of our Projects, Publications, and Discoveries

A summary of the research and publications produced by our team over the last two years.

View our presentation - Carbone-Full-Presentation-06042017.pdf
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