Association of SV40 with human tumors
Meeting Report: Studies conducted by the various investigators were presented addressing the association of SV40 with human mesothelioma. Joseph Testa (Fox Chase Cancer Center, Philadelphia, PA, USA) reported the conclusions of a multi-laboratory study he had directed following the recommendation of the 1997 NIH conference (see Carbone et al. (1997b) for meeting review of 1997 NIH conference) and upon the request of the International Mesothelioma Interest Group (IMIG).
Authors: George Klein, Amy Powers and Carlo Croce
Cancer Research, November 2008: Volume 68, Issue 22
Suppression of the late gene expression, usually by integration of the viral DNA into the host genome, is a critical step in DNA tumor virus carcinogenesis. SV40 induces high rates of transformation in infected primary human mesothelial cells in tissue culture, leading to the formation of immortal cell lines (SV40-transformed human mesothelial cell lines, S-HML).
Nature Reviews: Cancer (2002)
An increasing number of scientific reports have described evidence for a polyomavirus, simian virus 40, in a highly select group of human tumors. How did a simian virus infect humans and is the virus a passenger in tumours or is it important in their pathogenesis?
Authors: Adi F. Gazdar, Janet S. Butel & Michele Carbone