We hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of MM, BAP1-associated cancers, or multiple malignancies; or age younger than 50 years old.
Authors: Sandra Pastorino, Yoshie Yoshikawa, Harvey I. Pass, Mitsuru Emi, Masaki Nasu, Ian Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Manaai, Tomoko Hashimoto-Tamaoki, Masaki Ohmuraya, Keisuke Goto, Chandra Goparaju, Kavita Y. Sarin, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Mary Hesdorffer, and Michele Carbone.
For the past 10 years, the Virginia & Barry Weinman Foundation, in conjunction with the University of Hawaii Cancer Center, has sponsored an annual meeting of top researchers from around the world. This publication in Cell Death & Differentiation (6 August 2018) is a consensus report about the role of genes and environment in carcinogenesis.
Cell Death and Differentiation, June 30, 2017 (doi: 10.1038/cdd.2017.95)
Aerobic glycolysis, also known as the ‘Warburg effect’, does not necessarily occur as an adaptive process that is consequence of carcinogenesis, but rather that it may also predate malignancy by many years and facilitate carcinogenesis.
Nature International Weekly Journal of Science (2017) - doi:10.1038/nature22798
A mechanistic rationale for the ability of BAP1 to regulate gene-environment interaction in human carcinogenesis
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