Michele Carbone's Collaborators and Lab Team at the University of Hawaii Cancer Center
Our team works in the beautiful Cancer Center at the University of Hawaii. This photo shows our team gathered together for a farewell lunch for one of our members. We are standing on the lanai (exterior patio) of the Cancer Center. Our laboratory is on this same floor. Colleagues from left to right: Cathy Zhang, Wen Ming Chu, Valentina Signorato, Masaki Nasu, Gwen Ramelb, Brandon Taylor, Sandra Pastorino, Mika Tanji, David Larson, Haining Yang, Makana (a famous singer, not part of our lab), Angela Bononi, Michele Carbone, Agata Szymiczek, Xhongjian Chen, Jiaming Xue
I am studying the role of BAP1 in cell survival, proliferation and metabolism, in order to understand how BAP1+/- cells are predisposed to malignant transformation. Our final goal is to identify new molecular targets or cellular pathways that could be targeted for therapeutic intervention, or used as early diagnostic tools for cancer prevention.
I am very excited to be a member of this nice team. Since I have worked as a medical doctor and studied basic research about transcriptional regulation in the cancer biology, I would like to study more deeply about things that have not yet been elucidated in the clinical settings. Now I am challenged by two big projects involving the roles of BAP1 and HMGB1 in mesothelioma.
I am a research assistant and I aid in various projects, mainly in genetic and genealogical research. Additionally, I ensure laboratory maintenance and organization..
We do genetic testing especially on BAP1 mutations for Malignant Mesothelioma patients and their family members. We are searching for more new mutated genes, which predispose individuals to Malignant Mesothelioma and other cancers. Our goal is to identify the cancer syndrome for Cancer prevention and therapy.
I was born and raised in Honolulu, Hawaii and feel blessed to be a part of an amazing international mesothelioma research team
I am a clinical oncologist from Japan and having an exciting time working on early detection of malignant mesothelioma and the BAP1 syndrome.
I extract and analyze the DNA of mesothelioma patients. I decided to work in this lab because I want to understand cancer and contribute my time to the progress of cancer research.
I am a PhD student working under the tutelage of Dr. Haining Yang to explore the possible proteomic linkage between BAP1 and HMGB1.
I am studying why large scale mutations occur in the genome during cancer cell carcinogenesis. I hope we can elucidate the mechanisms affecting of the development of mesothelioma.
My main interests in the Dr. Yang's lab were characterizing asbestos-induced inflammation and determining the role of specific cell types in the development of mesothelioma.
From 2008 to 2013, I worked in Dr. Michele Carbone’s lab, where I learned to be a professional scientist. I remember all the amazing memories and am so proud to be a part of this
team. My research interests were 1. to investigate the tissue tropism and transforming potential of SV40 and 2. to characterize the possible transforming potential of chrysotile fibers.
I was part of Carbone’s team between 2007-2012. My research focused on identifying new targets for therapy as well as studying key events that influence chemotherapy resistance in mesothelioma. One of the targets I discovered was the CSPG4 protein, already known to be associated with a highly metastatic form of melanoma, is required for malignant mesothelioma cell adhesion as a co-receptor to other growth factors. With the help of Drs. Carbone and Gaudino, I initiated a highly productive collaboration with Dr. Soldano Ferrone at the University of Pittsburgh that increased our understanding of the role of CSPG4 protein and its use as a target in immunotherapy for mesothelioma and extending this therapeutic work on CSPG4 in combination with chemotherapy. In addition, I participated in several projects on the exposure of erionite leading to high incidence of MM in murine models.
I worked in Michele Carbone’s lab from 1993 until 2001. During this time, as a molecular biologist, I contributed to the discovery of SV40 DNA sequences and the identification of a protein complex between the SV40 large T antigen and p53 in human mesothelioma specimens. Subsequently, in order to shed lights on the origin of monkey viral sequences found in human tumors, I performed comparative sequencing analyses of several regions of the SV40 genome identified both in human tumor and in polio vaccines produced before 1963, known to contain SV40 virus as a contaminant.
I worked in Dr. Carbone's and Dr. Yang's laboratory as a Student Intern from the University of Ferrara, Faculty of Pharmacy. I joined Dr. Carbone’s Lab for my thesis research to study cells signaling mechanisms in cells derived from individuals carrying germline BAP1 mutations (BAP1+/-).
I always dreamed of working on a team with passion and wisdom. I have been realizing that dream since joining this team.
I am a research specialist and I focus on the novel anti-cancer therapeutics proposed for the treatment of malignant mesothelioma, whose efficacy needs to be established in vitro and in vivo.